Three distinct secreted aspartyl proteinases in Candida albicans.

Candida albicans

The secreted aspartyl proteinases of Candida albicans (products of the SAP genes) are thought to contribute to virulence through their effects on Candida adherence, invasion, and pathogenicity. From a single strain of C. albicans (WO-1) which expresses a phenotypic switching system, three secreted aspartyl proteinases have been identified as determined by molecular weight and N-terminal sequenc...

Proteinases in Virulence and Pathogenesis Secreted Aspartyl Candida albicans

The inhibition of Candida albicans secreted aspartyl proteinase by triangular gold nanoparticles

Objective(s): The aim of this study was to synthesize triangular gold nanoparticles, and then to evaluate their capability for inhibition of Candida albicans secreted aspartyl proteinase 2(Sap2).Materials and Methods: To synthesize the nanoparticles, hydrogen tetrachloroaurate and hexadecyl trimethyl ammonium bromide were incubated in presence of Sn(IV) meso-tetra(N-methyl-4-pyridyl) porphine t...

Role of Aspartic Proteinases in Candida Albicans Virulence. Part I. Substrate Specificity of Aspartic Proteinases and Candida Albicans Pathogenesis Rola Proteazy Aspartylowej W Wirulencji Candida Albicans Część I. Specyficzność Substratowa Proteazy Aspartylowej a Patogeneza Zakażeń Candida Albicans

Candida albicans resides mainly as a harmless commensal in the gastrointestinal tract, vagina and some cutaneous areas of humans. However, in individuals who are immunocompromised or debilitated in some other way, C. albicans is responsible for superficialy-localized or systemic infections. Candida albicans produces a large family of secreted aspartyl proteinases (Saps) which are key virulence ...

Candida albicans secreted aspartyl proteinases in virulence and pathogenesis.

Candida albicans is the most common fungal pathogen of humans and has developed an extensive repertoire of putative virulence mechanisms that allows successful colonization and infection of the host under suitable predisposing conditions. Extracellular proteolytic activity plays a central role in Candida pathogenicity and is produced by a family of 10 secreted aspartyl proteinases (Sap proteins...